Role of cryopreserved placenta extract in prevention and treatment of paracetamol-induced hepatotoxicity in rats

Background/Aim: Drug-induced liver injury is one of the major causes acute failure. Under current circumstances pandemic COVID-19, use paracetamol which has a proven hepatotoxic effect increased. This prompts search for novel agents with hepatoprotective properties. The purpose this article was to evaluate activity cryoextract placenta (CEP) on model paracetamol-induced hepatitis. Methods: study performed 28 male rats. Acute drug damage modelled by intragastric administration twice at dose 1250 mg/kg. Results: development hepatitis in rats accompanied 71.3 % increase (p < 0.001) content active products thiobarbituric acid (TBA-AP) homogenates as compared intact animals. Besides, there 2.1-fold ALT activity, 58.8 AST and 4.2-fold concentration total bilirubin cryopreserved extract showed significant hepatoprotection rat demonstrated 2.3-fold 0.01) antioxidant-prooxidant index, decrease (by 44.0 %) 29.6 %), well direct level 52.5 animals treated CEP without treatment. Conclusion: associated activation lipid peroxidation processes tissues, while marked